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Updated: Jan 7, 2026
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Elucidating the Ferroptotic Black Box: Radical-Trapping Antioxidant Probes Illuminate Subcellular Onset and
Jiaying Huang1, Cuiling Ouyang1, Zijun Wu1
1State Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
None:
Ferroptosis is a form of iron-mediated regulated cell death driven by lipid peroxidation (LPO). It has not only further improved our understanding of the cell death mechanism but also shown enormous potential in therapeutic applications. While the precise subcellular itinerary of ferroptotic cell death remains a subject of ongoing debate, radical-trapping antioxidants (RTAs) are widely recognized as efficient antiferroptotic agents due to their ability to interrupt LPO chain propagation. Here, we highlight recent pioneering works in the field, showing how probes derived from RTAs serve as powerful chemical tools for resolving the mechanism of ferroptosis across multiple cellular compartments.
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