Related Experiment Video
Updated: Jan 7, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
[Clinical characteristics and prognosis of primary immune thrombocytopenia complicated with diffuse alveolar
1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Beijing 100044, China.
Abstract:
Objective: This study aimed to investigate the clinical characteristics and prognosis of primary immune thrombocytopenia (ITP) complicated with diffuse alveolar hemorrhage (DAH) . Methods: This study retrospectively analyzed the clinical data of five patients with ITP complicated with DAH admitted to Peking University People's Hospital from January 2015 to June 2024. Basic characteristics, clinical symptoms, laboratory tests, imaging findings, and treatment responses were summarized, and survival and prognostic factors were evaluated. Results: All patients were female, with a median age of 56 (38-66) years. Four cases were diagnosed with chronic ITP, and three cases were complicated by infection. The main symptoms included mucocutaneous bleeding (3/5), dyspnea (3/5), and hemoptysis (2/5). The median PLT was 51 (1-83) ×10(9)/L. D-dimer was significantly increased [median 870 (220-8 578) ng/ml]. Chest computed tomography revealed diffuse ground-glass opacities in both lungs (3/5), consolidation (1/5), and air bronchogram (1/5). Three patients achieved complete remission, whereas two patients died. Conclusion: ITP complicated by DAH mainly manifests as acute respiratory failure. Increased D-dimer and failure to control infection are high-risk factors for death. Therefore, early combined immunosuppression and anti-infection treatment improves prognosis.
Related Concept Videos
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Pulmonary Embolism I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...

