Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac...

Cardiac patches demonstrate promise in the treatment of myocardial infarction (MI). However, their clinical application encounters challenges, particularly electrical coupling instability, impairing myocardial contractility and functional reconstruction. Here, we developed a super-conductive ionic patch with high electrical stability and biocompatibility based on a choline-derived bio-ionic liquid (Bio-IL). The patch formed multiple interactions with the cardiac interface, including covalent bonds and ionic interactions, achieving rapid and stable adhesion. In the infarcted area, -N(CH₃)₃⁺ in Bio-IL dynamically interacted with host anions, enabling mutual ionic migration and consistent electrical signal transmission. The electrophysiological integration and reparative effects of the patch were evaluated in rat and mini-pig MI models. Results demonstrated enhanced electrical signal conduction within the infarcted area, increased conduction velocity, shortened durations of depolarization and repolarization, and suppressed excitation-contraction decoupling. Furthermore, the patch significantly reduced infarct size, improved ejection fraction, and restored cardiac function. These findings underscore the potential of the patch for further clinical translation in MI therapy.