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Related Concept Videos

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...

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Updated: May 27, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Localised Herpes Simplex Following Midline Laparotomy.

Jessica S Bulluss1, Paul Chee1, Matthew J Verheyden1

  • 1John Hunter Hospital, Newcastle, New South Wales, Australia.

The Medical Journal of Australia
|January 5, 2026
PubMed
Summary
This summary is machine-generated.

A rare case of localized herpes simplex virus infection occurred after abdominal surgery in a patient with Crohn's disease. This viral complication, confirmed by PCR, highlights a potential risk following invasive procedures.

Keywords:
Herpesviridae infectionsinfectious diseaselaparotomyskin diseases

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Surgical Complications

Background:

  • Crohn's disease is a chronic inflammatory condition requiring surgical intervention for complications like perforation.
  • Abdominal surgery carries risks, including surgical site infections.
  • Herpes simplex virus (HSV) infections are common but localized post-surgical manifestations are rare.

Purpose of the Study:

  • To report the first case of localized herpes simplex virus infection following abdominal surgery.
  • To describe the clinical presentation and diagnostic findings of this rare complication.

Main Methods:

  • Case report of an older male patient with Crohn's disease.
  • Emergency laparotomy for small bowel perforation.
  • Clinical observation of a peri-incisional eruption.
  • Histopathological examination and immunohistochemistry for viral identification.
  • Polymerase chain reaction (PCR) for HSV-1 DNA confirmation.

Main Results:

  • A vesiculobullous eruption developed 5 days post-surgery near the incision.
  • Histopathology revealed viral cytopathic changes.
  • Immunohistochemistry confirmed the presence of herpes simplex virus.
  • PCR testing definitively identified HSV-1 DNA.

Conclusions:

  • Localized herpes simplex virus infection is a potential, albeit rare, complication of abdominal surgery.
  • Early diagnosis through histopathology and molecular testing is crucial.
  • This case underscores the importance of considering viral etiologies in post-operative dermatological manifestations.