Quercetin Hybrids and their Biological Potential

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Drug Discovery

Background:

• Infectious diseases are a growing global health threat, necessitating new treatments.
• Molecular hybridization is a key strategy for developing effective therapeutic agents.
• Quercetin, a natural flavonoid, provides a versatile scaffold for creating hybrid molecules.

Purpose of the Study:

• To review and analyze research on quercetin-based hybrids for disease management from 2005 to 2024.
• To explore the relationship between structural modifications and biological activity.
• To assess the therapeutic potential of quercetin derivatives.

Main Methods:

• Literature search and qualitative synthesis of studies on quercetin hybrids.
• Extraction of data on chemical structure, synthesis, biological activity, and experimental models.
• Analysis focused on structure-activity relationships and therapeutic relevance.

Main Results:

• Quercetin hybrids demonstrate broad-spectrum activity against infectious, inflammatory, and degenerative diseases, and cancers.
• Structural modifications enhance pharmacological properties, improving solubility and bioavailability.
• A strong correlation exists between specific structural changes and observed biological effects.

Conclusions:

• Quercetin hybrids are potent, nature-inspired therapeutic candidates.
• Tailoring quercetin's structure offers a rational approach for designing novel drugs.
• These compounds hold significant potential for future drug development.