Arsenic Exposure and Neurodevelopmental Disorders in Children: A Cross‑Sectional Study
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View abstract on PubMed
Summary
This summary is machine-generated.Arsenic exposure in children from Arica is linked to a higher prevalence of neurodevelopmental disorders (NDDs), including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Elevated urinary arsenic levels indicate increased risk for these developmental conditions.
Area Of Science
- Environmental Health
- Neuroscience
- Pediatrics
Background
- Arsenic exposure is a potential risk factor for neurodevelopmental disorders (NDDs).
- Previous research in Arica focused on arsenic and attention deficit hyperactivity disorder (ADHD), necessitating further investigation into other NDDs like autism spectrum disorder (ASD).
Purpose Of The Study
- To evaluate the association between current urinary arsenic concentration and the prevalence of NDDs in children residing in Arica.
- To explore the relationship between arsenic exposure and specific NDDs, including ADHD and ASD.
Main Methods
- A cross-sectional study utilizing secondary data from the FONIS project #SA22I0119.
- Involved 450 children born between 2013 and 2016, with NDD diagnosis determined by parent self-reporting.
- Measured urinary inorganic arsenic concentration, adjusted for creatinine, and employed logistic regression analysis accounting for confounding variables.
Main Results
- The prevalence of ADHD was 9.1%, ASD 5.3%, and overall NDDs 12%.
- A mean urinary inorganic arsenic concentration of 19.8 μg/g creatinine was observed, with 7.6% of children exceeding 35 μg/g.
- Children with urinary arsenic levels ≥35 μg/g creatinine showed a significantly higher likelihood of presenting with NDDs (OR: 2.93) and ADHD (OR: 3.85) after adjusting for confounders.
Conclusions
- Findings suggest a significant association between arsenic exposure and the prevalence of NDDs in children.
- Results contribute to the growing body of evidence on the detrimental effects of arsenic on child neurodevelopment.
- Highlights the need for public health interventions to mitigate arsenic exposure in vulnerable populations.
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