Polymer-Coated Iron Oxide Nanoparticles as an Effective Tool for Histamine Extraction: Synthesis, Characterization,...

Area of Science:

• Materials Science
• Food Science
• Nanotechnology

Background:

• Histamine accumulation in food presents health risks, requiring effective removal methods.
• Current methods for histamine reduction are often inefficient or costly.

Purpose of the Study:

• To synthesize and optimize poly-(acrylic acid-co-methacrylic acid)-coated iron oxide nanoparticles (ION@P-(AA-co-MAA)) for histamine adsorption.
• To evaluate the performance of these nanoparticles in histamine extraction from food-mimicking solutions.

Main Methods:

• Combined Plackett-Burman and central composite design for synthesis optimization.
• Characterization of nanoparticle size, surface charge, and polymer coating.
• Histamine adsorption capacity testing in various buffers, including soy sauce mimic.
• Magnetic separation and reusability assessment.

Main Results:

• Optimized ION@P-(AA-co-MAA) nanoparticles exhibited significant histamine adsorption capacities (up to 130.5 mg/g).
• Particles demonstrated efficient magnetic separation due to superparamagnetic properties.
• High adsorption capacity (55 mg/g) was achieved in a soy sauce-mimicking buffer.
• Reusability was confirmed, indicating practical application potential.

Conclusions:

• Functionalized magnetic nanoparticles offer a promising solution for histamine removal in food.
• The developed platform is scalable, reusable, and effective in complex food matrices.
• This advancement supports the production of safer food products with reduced histamine levels.