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Miller Fisher Variant of Guillain-Barré Syndrome Presenting With Dysphagia and Ophthalmoplegia
Rupam Sharma1, Sanjana Murdande1, Jose Garcia-Corella1
1Internal Medicine, University of California, Los Angeles (UCLA) Kern Medical, Bakersfield, USA.
Abstract:
Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome (GBS). It is characterized by a triad of ataxia, areflexia, and ophthalmoparesis. Akin to GBS, it is often triggered by a respiratory infection, causing immune cross-activation against pathogenic proteins and gangliosides. Symptoms typically occur in chronological progression, beginning with ophthalmoparesis, then ataxia, and finally areflexia. Our case is of a patient presenting with dysphagia and ophthalmoplegia as the initial manifestations. There currently exist only a limited number of reported cases of MFS presenting with dysphagia, which, along with ophthalmoplegia, areflexia, and ataxia, should raise suspicion for MFS.
Insights
Miller Fisher syndrome (MFS), a rare Guillain-Barré syndrome variant, presents with ataxia, areflexia, and ophthalmoparesis. This case highlights dysphagia and ophthalmoplegia as initial MFS symptoms, suggesting broader diagnostic criteria.
Area of Science:
- Neurology
- Immunology
Background:
- Miller Fisher syndrome (MFS) is a rare neurological variant of Guillain-Barré syndrome (GBS).
- MFS classically presents with ophthalmoparesis, ataxia, and areflexia.
- It is often triggered by infections, leading to immune responses against gangliosides.
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