Related Experiment Video
Updated: Jan 7, 2026
An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
Published on: June 24, 2025
Risk factors for neonatal catheter-related bloodstream infections: a systematic review and meta-analysis
Shuai Wang1, Lihong Chi2, Xingye Zhou3,4
1Outpatient Department, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
Insights
Catheter-related bloodstream infections (CRBSI) in newborns are linked to factors like catheter type, Apgar scores, and duration. Identifying these risks helps create prevention strategies for better infant outcomes.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Public Health
Background:
- Catheter-related bloodstream infection (CRBSI) is a significant nosocomial infection in neonatal intensive care units.
- CRBSI can lead to prolonged hospitalization, severe harm, and increased mortality in newborns.
- Existing research on CRBSI risk factors in neonates is inconsistent, necessitating a comprehensive analysis.
Purpose of the Study:
- To systematically investigate and identify risk factors associated with CRBSI in neonates.
- To provide an evidence-based foundation for developing effective CRBSI prevention strategies in neonatal populations.
- To enhance decision-making processes for reducing CRBSI incidence in high-risk newborns.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, Web of Science, Scopus, CNKI, Wanfang) up to October 2025.
- The Newcastle-Ottawa Scale (NOS) was used for quality assessment of included studies.
- Meta-analysis was performed using RevMan 5.3, with heterogeneity assessed by the I² statistic and publication bias by funnel plot tests.
Main Results:
- Eighteen articles comprising 11,963 neonates were included in the meta-analysis.
- Key risk factors for neonatal CRBSI, from strongest to weakest association, include: multi-lumen central venous catheters (≥2), low 5-min Apgar score (≤7), frequent manipulations (≥2), prolonged catheter dwell time (>14 days), prematurity (gestational age ≤32 weeks), parenteral nutrition, maternal disease, low birth weight (<1,500g), male sex, and limb catheterization.
- All identified factors demonstrated a significant association with the development of CRBSI.
Conclusions:
- This meta-analysis highlights critical modifiable risk factors for CRBSI in neonates.
- An evidence-based prevention bundle targeting catheter dwell time, aseptic techniques, and nutrition management is proposed.
- Implementing this bundle can reduce CRBSI incidence, improve resource efficiency, and enhance outcomes for high-risk neonates.
Background:
Catheter-related bloodstream infection (CRBSI) is a prevalent nosocomial infection in neonatal units. The incidence of CRBSI can prolong hospitalization, cause irreparable harm, and negatively affect newborn survival and quality of life. Previous research has identified risk factors for CRBSI, but the findings have been inconsistent, and all predisposing factors have not been systematically described. This study aimed to investigate the risk factors for developing CRBSI in neonates and to provide a scientific basis for decision-making in the prevention of neonatal CRBSI.
Methods:
A systematic search of PubMed, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), and the Wanfang Database was performed from the time of each database's inception to 1 October 2025. The search strategy combined subject terms and free-text keywords. The Newcastle-Ottawa scale (NOS) was used to assess the quality of the literature, and meta-analysis was carried out using RevMan 5.3. Heterogeneity was evaluated using the I2 statistic method, and publication bias was analyzed with funnel plot tests.
Results:
A total of 18 articles involving 11,963 participants were included in this study. In the meta-analysis, the risk factors for the development of CRBSI in neonates, ranked from strongest to weakest association, were as follows: Multi-lumen central venous catheters (CVCs) ≥ 2, 5-min Apgar score≤7, number of manipulations≥2, catheter indwelling time>14d, gestational age≤32w, parenteral nutrition (PN), maternal disease, birth weight<1,500 g, male sex, and catheterization of the upper and lower limbs. These risk factors were found to be significantly associated with the development of CRBSI.
Conclusion:
This meta-analysis identifies key modifiable risk factors for CRBSI in neonates, informing a proposed evidence-based prevention bundle. This bundle targets factors such as catheter dwell time, aseptic technique, and nutrition management to reduce CRBSI incidence and improve resource efficiency, especially in high-risk neonates.
More Related Videos
03:24Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
Published on: March 22, 2024
09:57A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Related Concept Videos
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:26Cardiac Catheterization IV: Nursing Management
01:28Cardiac Catheterization I: Pre-Procedure Overview
01:25Urinary Tract Infection II: Pathophysiology