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Updated: Jan 7, 2026

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Intervention strategies for cancer-related sarcopenia: a scoping review

Lei Li1, Haiyan Zhu2, Jiangxia Chen3

  • 1Department of Gastrointestinal Surgery, Shaoxing People's Hospital, The First Hospital of Shaoxing University, Shaoxing, Zhejiang, China.

Frontiers in Nutrition
|January 5, 2026
PubMed
Abstract

Insights

Effective cancer-related sarcopenia (CRS) treatment requires integrated strategies combining nutrition, exercise, and medical interventions. Multidisciplinary teams are key for improving patient outcomes and quality of life.

Area of Science:

  • Oncology
  • Gerontology
  • Rehabilitation Medicine

Background:

  • Cancer-related sarcopenia (CRS) significantly impacts patient prognosis and quality of life.
  • Current intervention strategies for CRS lack a unified, evidence-based approach.
  • There is a need to synthesize existing research on CRS interventions to guide clinical practice and future research.

Purpose of the Study:

  • To systematically review and categorize intervention strategies for cancer-related sarcopenia (CRS).
  • To provide evidence-based insights for developing targeted and effective treatments for CRS.
  • To identify gaps and future directions in CRS research.

Main Methods:

  • Systematic literature search of major databases (PubMed, Embase, Web of Science, Cochrane Library) from 2015 to 2025.
  • Inclusion of 18 randomized controlled trials (RCTs) published between 2016 and 2025.
  • Content analysis and categorization of CRS interventions into nutritional, exercise, pharmacological, and multidisciplinary approaches.

Main Results:

  • A total of 3,566 articles were initially screened.
  • Eighteen RCTs met the inclusion criteria, with sample sizes ranging from 15 to 232 participants.
  • Interventions were classified into four main categories: nutritional, exercise, pharmacological, and multidisciplinary.

Conclusions:

  • An integrated approach combining nutrition, exercise, pharmacology, and a multidisciplinary team (MDT) is essential for managing CRS.
  • This integrated strategy aims to enhance patients' functional outcomes and overall quality of life.
  • Future research should prioritize precision medicine and translational approaches for CRS treatment.
Keywords:
cancerintervention strategiesrandomized controlled trial (RCT)rehabilitationsarcopenia

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