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Updated: Jan 7, 2026

Listeria monocytogenes Infection of the Brain
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Can bacteria control the human brain?

G M Berdichevskiy1,2, E I Ermolеnko1, A N Suvorov1,2

  • 1Institute of Experimental Medicine, Saint Petersburg, Russia.

Communicative & Integrative Biology
|January 5, 2026
PubMed
Summary
This summary is machine-generated.

The gut microbiome significantly influences central nervous system (CNS) disorders. This review explores the gut-brain axis, identifying specific microbial strains and mechanisms impacting neurological conditions.

Keywords:
BehaviorGABAbiochemistrybiological communicationevolutionary biologymolecular biologymolecules

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Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Increasing prevalence of nervous, neurodegenerative, and gastrointestinal diseases.
  • Established bidirectional communication between the nervous and digestive systems via the microbiota-gut-brain axis, circulatory, and immune systems.

Purpose of the Study:

  • To compile and summarize existing literature on the gut's influence on CNS disorders.
  • To identify common patterns and specific microbial strains impacting neurological pathologies.
  • To elucidate the mechanisms by which gut microbiota affects brain function.

Main Methods:

  • Comprehensive literature review and synthesis.
  • Analysis of existing data on the microbiota-gut-brain axis.
  • Identification of correlations between gut microbial composition and CNS disorders.

Main Results:

  • The gut microbiome plays a significant role in the development and progression of CNS disorders.
  • Specific gut microbial strains show potential as therapeutic targets for neurological conditions.
  • The microbiota influences the brain through various pathways, including immune and neural signaling.

Conclusions:

  • The gut microbiome is a critical factor in central nervous system health and disease.
  • Targeting the gut microbiota offers promising therapeutic strategies for neurodegenerative and other CNS disorders.
  • Further research into specific microbial mechanisms is warranted to optimize interventions.