Rise of the Resistance: A Case of Resistant Shigellosis in an Immunocompetent Female Patient

Shigellosisis a common enteric infection with updated empiric treatment guidance due to the emergence of resistant isolates. Herein, we describe a case of resistant shigellosis in an immunocompetent female with no recent travel. The patient initially started ciprofloxacin, but due to ongoing gastrointestinal symptoms and intermediate resistance to fluoroquinolones on stool culture, she was later switched to azithromycin. We believe this case demonstrates the looming threat of multidrug-resistant Shigella, even among those without risk factors or recent antibiotic use. This case also highlights the importance of stool culture susceptibility testing.