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Bioinformatic Analysis of RNF43 and Its Co-expressors As Prognostic Biomarkers for Gastric Cancer
Masanobu Tsubaki1, Taira Matsuo1, Rie Komori1
1Laboratory of Pharmacotherapy, Tokushima Bunri University, Takamatsu, JPN.
Cureus
|January 5, 2026
Summary
High expression of ring finger protein (RNF)-43 and AXIN2 indicates better survival for gastric cancer patients. Conversely, hormonally upregulated Neu-associated kinase (HUNK) is linked to poorer outcomes, suggesting it as a potential therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genomics
Background:
- Gastric cancer (GC) presents a significant global health challenge with high mortality rates.
- Current treatments like surgery and chemotherapy offer survival benefits, but identifying new prognostic factors is crucial for patients with poor prognoses.
- The role of ring finger protein (RNF)-43, a Wnt pathway regulator, in GC prognosis is not fully understood.
Purpose of the Study:
- To investigate the prognostic impact of RNF43 and its co-expressed genes on the survival of gastric cancer patients.
- To identify potential biomarkers for predicting gastric cancer patient outcomes.
Main Methods:
- Analysis of publicly available clinical datasets using bioinformatics tools (UALCAN, cBioPortal, Kaplan-Meier plotter, Linkedomics, WebGestalt).
- Evaluation of RNF43 expression levels and its correlation with overall survival (OS).
- Identification and analysis of RNF43 co-expressing genes (AXIN2, ZNRF3, BAMBI, HUNK) and their impact on GC prognosis.
Main Results:
- Elevated RNF43 expression was associated with prolonged overall survival in gastric cancer patients.
- AXIN2 co-expression with RNF43 also correlated with improved patient OS.
- Overexpression of HUNK was identified as a poor prognostic factor, while combined RNF43 and HUNK expression suggested prolonged OS compared to HUNK alone.
Conclusions:
- RNF43 and AXIN2 are identified as favorable prognostic factors for gastric cancer.
- HUNK serves as a poor prognostic factor and a potential therapeutic target in gastric cancer.
- Understanding the interplay between RNF43, AXIN2, and HUNK can refine prognostic assessments and guide treatment strategies for GC.
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