Noninvasive transcranial brain stimulation for eye diseases and visual dysfunctions: A systematic review of RCTs

Noninvasive transcranial brain stimulation (NTBS) has emerged as a potential therapeutic approach for eye diseases and visual dysfunctions. This systematic review evaluates the evidence from 23 randomized controlled trials examining the application of NTBS, including transcranial electrical stimulation and transcranial magnetic stimulation, in conditions such as amblyopia, myopia, visual field defects, glaucoma, diabetic retinopathy, macular degeneration, and blepharospasm. Studies assessed outcomes such as visual acuity, contrast sensitivity, and visual perception, with variable effects observed across trials. Most studies reported no serious adverse events, indicating that NTBS is safe and feasible. However, conclusive evidence regarding its efficacy remains elusive due to varied interventions, inconsistent outcome measures, and methodological limitations. Future research with higher methodological rigor is needed to optimize stimulation parameters and explore integration with adjunctive therapies.