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Anticoagulant Therapy in Neonatal Acute Infectious Peritonitis Based on the TAT, PIC, t-PAIC, and sTM: A New Case
Wenya Wang1,2, Yue Gao1,2, Yan Qiao3
1Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China.
Abstract:
Neonatal acute peritonitis is a leading cause of morbidity and mortality and poses challenges that demand prompt diagnosis and treatment, particularly in infants with disseminated intravascular coagulation. Here, we report a case series of four infants with acute peritonitis caused by necrotizing enterocolitis, gastrointestinal perforation, and meconium peritonitis. Laboratory tests for thrombin-antithrombin III complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC), soluble thrombomodulin (sTM), and tissue plasminogen activator-inhibitor complex (t-PAIC) suggested the activation of the coagulation system followed by treatment with anticoagulant therapy in these infants. Overall, TAT, PIC, t-PAIC, and sTM may guide anticoagulant therapy, offering prospects for improving the outcomes in neonates with acute peritonitis.
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