Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Scleroderma calcinosis cutis score (SC2S): an imaging metric to quantify SSc-calcinosis cutis.

Rheumatology (Oxford, England)·2026

Same author

CD64 binding potential does not translate into enhanced therapeutic efficacy for anti-IL-23 antibodies under physiologically relevant conditions.

Molecular medicine (Cambridge, Mass.)·2026

Same author

MC1R determines healing outcomes in acute and chronic cutaneous wounds.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases.

Nature communications·2025

Same author

Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody.

Blood·2025

Same author

Atgl-Dependent Adipocyte Lipolysis Promotes Lipodystrophy and Restrains Fibrogenic Responses during Skin Fibrosis.

The Journal of investigative dermatology·2025

Same journal

Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.

Frontiers in immunology·2026

Same journal

Circadian control of immune homeostasis in cardiovascular health and disease.

Frontiers in immunology·2026

Same journal

An IHC-derived TLS-CD8-macrophage immune niche score predicts major pathological response to neoadjuvant chemoimmunotherapy in resectable NSCLC.

Frontiers in immunology·2026

Same journal

AF6 orchestrates macrophage polarization via JAK2-STAT3 signaling and supports intestinal regeneration by stimulating stem cell proliferation.

Frontiers in immunology·2026

Same journal

Restoring immune homeostasis in the spinal microenvironment: targeting mechano-inflammation and immunometabolic reprogramming.

Frontiers in immunology·2026

Same journal

A self-perpetuating neuron-intrinsic GSDMD-mtDNA-AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury.

Frontiers in immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 2, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

Editorial: Exploring immune-stromal cell dynamics: pathways and therapeutic implications

Stacy Ryu¹, Stephen B Gauld¹, Matthew M Staron¹

¹Abbvie Inc., North Chicago, IL and Cambridge, MA, United States.

Frontiers in Immunology

|January 5, 2026

Summary

No abstract available in PubMed .

Keywords:

cell-cell interactions fibroblast and immune crosstalk mesenchymal stem/stromal cells tertiary lymphoid structures tissue resident immune cells

More Related Videos

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Related Experiment Videos

Last Updated: May 2, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025