Reinforcement Learning and Decision Making in Depression in Adolescents and Young Adults: Insights from a New Model...

Depression is a prevalent psychiatric condition that commonly emerges in adolescence and young adulthood and is associated with reward processing abnormalities. The Probabilistic Reward Task (PRT) is widely used to investigate the impact of depression on reward processing, but prior studies have not comprehensively addressed the reinforcement learning and decision-making mechanisms involved in the task. In 726 adolescents and young adults with varying levels of depression, we collected PRT data and applied a novel computational model with response-outcome learning and evidence accumulation processes to provide new insights into the cognitive processes implicated in depression. Compared to participants with no history of psychopathology, those with depressive disorders showed reduced impact of learned response values on decision bias toward the more frequently rewarded action. In addition, higher levels of anhedonia were associated with slower evidence accumulation during decision-making. Together, these findings improved our understanding of the reinforcement learning and decision-making mechanisms assessed by the PRT and their associations with depression.