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Updated: Jan 7, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis.

Cato E A Corsten¹, Ana M Marques², Elisabeth J Vinke^3,4

¹Department of Neurology, MS Center ErasMS, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Annals of Neurology

|January 5, 2026

Summary

This summary is machine-generated.

The rs10191329*A genetic variant is linked to earlier brain atrophy in middle-aged adults. This finding suggests broader implications for neurodegeneration beyond multiple sclerosis (MS).

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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

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Published on: January 9, 2020

Area of Science:

Neurogenetics
Neuroimaging
Aging

Background:

The risk allele rs10191329*A is known to correlate with increased disease severity and brain atrophy in multiple sclerosis (MS) patients.
Understanding the role of genetic factors in age-related brain changes is crucial for public health.

Purpose of the Study:

To investigate the association between the rs10191329 genetic variant and age-related brain atrophy in a general population.
To determine if the rs10191329*A allele contributes to brain volume changes in individuals without MS.

Main Methods:

Utilized a population-based cohort of 4,815 participants aged 45 years and older.
Analyzed 10,308 magnetic resonance imaging (MRI) scans using cross-sectional and longitudinal approaches.
Examined the association of the rs10191329*A allele with total brain volume and gray matter volume.

Main Results:

The rs10191329*A allele was significantly associated with lower total brain volume and gray matter volume in middle-aged participants (under 55 years).
No significant association was observed between the rs10191329*A allele and brain atrophy in older participants (55 years and older).

Conclusions:

The rs10191329*A allele may contribute to an earlier onset of brain atrophy in the general population.
The mechanisms underlying accelerated neurodegeneration influenced by this allele extend beyond the context of multiple sclerosis.