Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.1K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.1K
Antibiotic Selection00:57

Antibiotic Selection

59.3K
Overview
59.3K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

876
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
876
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.7K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

457
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
457
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A deep learning-based classification method for subclinical zonular laxity in AS-OCT images.

Frontiers in cell and developmental biology·2026
Same author

Integration of Cold Atmospheric Plasma and Light-Based Technologies for Surface Decontamination in Nonthermal Food Safety Applications.

Comprehensive reviews in food science and food safety·2026
Same author

Regulatory Roles of Adiponectin in Animal Reproduction: Molecular Insights from the Hypothalamic-Pituitary-Gonadal Axis.

Biomolecules·2026
Same author

Microgels prepared by microfluidics from structural design to practical applications: Development and challenge.

Advances in colloid and interface science·2026
Same author

Ultrasound-Assisted Covalent Conjugation of Walnut Albumin with Bound Polyphenols: Structural Modulation and Functional Enhancement.

Foods (Basel, Switzerland)·2026
Same author

Digital twin-centered food safety management systems: A review of IoT, AI, and blockchain integration for bacterial pathogen control.

Food research international (Ottawa, Ont.)·2026

Related Experiment Video

Updated: Jan 7, 2026

High Throughput Co-culture Assays for the Investigation of Microbial Interactions
07:00

High Throughput Co-culture Assays for the Investigation of Microbial Interactions

Published on: October 15, 2019

10.6K

Microbial interactions in facilitating antibiotic activity and resistance evolution.

Lujie Zhang1, Shenmiao Li2, Ziqi Liu1

  • 1College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.

Applied and Environmental Microbiology
|January 5, 2026
PubMed
Summary
This summary is machine-generated.

Microbial interactions in polymicrobial communities significantly impact antibiotic effectiveness and the spread of antibiotic resistance. Understanding these ecological dynamics is crucial for developing better antibiotic strategies.

Keywords:
antibiotic activityantibiotic resistanceecological contextmicrobial interactions

More Related Videos

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.3K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.6K

Related Experiment Videos

Last Updated: Jan 7, 2026

High Throughput Co-culture Assays for the Investigation of Microbial Interactions
07:00

High Throughput Co-culture Assays for the Investigation of Microbial Interactions

Published on: October 15, 2019

10.6K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.3K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.6K

Area of Science:

  • Microbiology
  • Ecology
  • Evolutionary Biology

Background:

  • Microorganisms in polymicrobial communities interact dynamically.
  • These interactions influence antibiotic activity and resistance.
  • Current understanding often overlooks ecological context.

Purpose of the Study:

  • To review mechanistic pathways of microbial interactions affecting antibiotic responses.
  • To explore how interactions reshape antibiotic-induced selective pressures.
  • To highlight the importance of ecological context in antibiotic resistance research.

Main Methods:

  • Literature review of studies on microbial interactions and antibiotic action.
  • Analysis of intra- and inter-specific interaction mechanisms.
  • Examination of evolutionary trajectories toward antibiotic resistance.

Main Results:

  • Microbial interactions modulate antibiotic efficacy at individual and community levels.
  • Interactions can accelerate or inhibit the emergence and spread of antibiotic resistance.
  • Ecological context significantly alters responses to antibiotic treatment.

Conclusions:

  • Microbial community ecology is essential for understanding antibiotic resistance.
  • Considering interactions can lead to more effective antibiotic strategies.
  • Future research should integrate ecological principles into antibiotic development and application.