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Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside

Zixian Xie1, Yumin Luo2,3, Ziping Han4

  • 1Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.

Translational Stroke Research
|January 5, 2026
PubMed

Insights

Enhancing DNA repair offers a promising strategy to reduce brain damage and improve recovery after ischemic stroke. This review explores therapeutic approaches targeting DNA damage response pathways for neuroprotection.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Neurology

Background:

  • Cerebral ischemic stroke treatment remains challenging despite reperfusion therapies.
  • DNA damage and the DNA damage response (DDR) are increasingly recognized in stroke pathophysiology.
  • Inflammatory and apoptotic pathways are key downstream mediators in stroke.

Purpose of the Study:

  • To review recent neuroprotective strategies modulating DNA damage and repair pathways in stroke.
  • To focus on therapeutic interventions for both clinical ischemic stroke patients and experimental models.
  • To explore future directions in DNA repair-based stroke therapies.

Main Methods:

  • Literature review of studies on DNA damage, repair, and neuroprotection in stroke.
  • Analysis of research focusing on modulating the DNA damage response (DDR) pathways.
  • Inclusion of findings from both human clinical studies and experimental stroke models.

Main Results:

  • Evidence highlights the critical role of DNA damage in stroke-induced neural injury.
  • Modulating DNA repair pathways shows potential for mitigating stroke damage.
  • Targeting DDR offers a promising therapeutic avenue for neuroprotection and functional recovery.

Conclusions:

  • Enhancing DNA repair represents a viable therapeutic strategy for ischemic stroke.
  • Further research into DDR modulation could lead to improved stroke outcomes.
  • Future studies should explore novel approaches to harness DNA repair mechanisms for neuroprotection.
Keywords:
DNA damage responseDNA repair enzymesIschemia–reperfusion injuryIschemic strokeMitochondrial DNA

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