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Updated: Jan 7, 2026

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Basic Science and Pathogenesis.

Ping Che1, Nan Zhang1

  • 1Tianjin Medical University General Hospital, Jin Tian, Jin Tian, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|January 5, 2026
PubMed
Summary
This summary is machine-generated.

Cerebral blood flow (CBF) changes correlate with brain metabolism and amyloid buildup in Alzheimer's disease (AD). This study links reduced CBF to hypometabolism and increased amyloid deposition in AD patients.

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Area of Science:

  • Neuroscience
  • Radiology
  • Medical Imaging

Background:

  • Cerebral blood flow (CBF) alterations are implicated in Alzheimer's disease (AD) pathogenesis.
  • The precise relationship between CBF, neurodegeneration, and amyloid-β deposition in AD remains unclear.
  • Investigating these links is crucial for understanding AD progression.

Purpose of the Study:

  • To explore the correlations between cerebral perfusion and metabolic/amyloid pathology in AD.
  • To quantify the association between CBF, measured via arterial spin labeling (ASL), and PET imaging findings.

Main Methods:

  • Sixty-four AD patients and 56 controls underwent ASL and PET scans.
  • Cerebral perfusion was assessed using AD-related perfusion pattern (ADRP), global CBF, and regional CBF.
  • 18F-fluorodeoxyglucose (FDG)-PET and 11C-Pittsburgh Compound B (PiB)-PET measured metabolism and amyloid deposition, respectively.

Main Results:

  • ADRP scores negatively correlated with metabolic activity (FDG SUVR) and positively with amyloid deposition (PiB SUVR) in specific brain regions.
  • Global and regional CBF showed complex correlations with both hypometabolism and amyloid deposition across various brain areas.
  • Specific regional CBF values were significantly associated with both FDG and PiB SUVR in AD patients.

Conclusions:

  • Cerebral blood flow is significantly correlated with hypometabolism in Alzheimer's disease.
  • CBF also demonstrates significant correlations with amyloid deposition in AD.
  • These findings highlight the interconnectedness of vascular, metabolic, and amyloid pathologies in AD.