What Would Mother Say? Whole Blood and RhD Alloimmunization in Trauma Resuscitation

Low-titer type O whole blood has demonstrated survival benefits and improved hemostatic resuscitation compared with component-based transfusion. Although alloimmunization is a concern for women of childbearing potential, more recent evidence suggests that the absolute risk is low compared with the need to preserve maternal life. The administration of whole blood to women of childbearing potential is safer with postexposure Rh immunoprophylaxis and modern advances in the management of fetal anemia.