Related Experiment Video
Updated: Jan 13, 2026
08:58
Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
530
Toward precision for bronchopulmonary dysplasia: Moving past current definitions
Matthew J Kielt1, Timothy D Nelin2, Steven H Abman3
1Comprehensive Center for Bronchopulmonary Dysplasia, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Summary
Bronchopulmonary dysplasia (BPD) is a complex lung disease in preterm infants. Recognizing BPD as a lifelong condition is crucial for developing targeted therapies and improving long-term outcomes.
Area of Science:
- Neonatology
- Pulmonology
- Genetics
Background:
- Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth.
- Current definitions of BPD do not fully encompass its complex and evolving nature.
- Persistent pulmonary issues are observed throughout the lifespan in individuals with BPD.
Purpose of the Study:
- To analyze the evolution and limitations of current BPD definitions.
- To propose a path forward for BPD research and treatment.
- To emphasize the lifelong impact of BPD and related cardiopulmonary diseases.
Main Methods:
- Review of longitudinal studies on BPD.
- Analysis of current BPD diagnostic criteria.
- Perspective on precision medicine approaches including deep phenotyping and multi-omic data integration.
Main Results:
- Existing BPD definitions are inadequate for capturing disease heterogeneity.
- Biomarkers for precise BPD endotyping and targeted therapies are still needed.
- Collaborative data networks and longitudinal outcome measures are essential.
Conclusions:
- Bronchopulmonary dysplasia (BPD) and related cardiopulmonary diseases are lifelong conditions.
- Precision medicine approaches are vital for identifying BPD subtypes and guiding individualized care.
- A shift in perspective is needed to view BPD beyond the neonatal intensive care unit (NICU) stay.
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