Related Experiment Video

Updated: Jan 13, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

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Toward precision for bronchopulmonary dysplasia: Moving past current definitions

Matthew J Kielt1, Timothy D Nelin2, Steven H Abman3

  • 1Comprehensive Center for Bronchopulmonary Dysplasia, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|January 6, 2026
PubMed

Insights

Bronchopulmonary dysplasia (BPD) is a complex lung disease in preterm infants. Recognizing BPD as a lifelong condition is crucial for developing targeted therapies and improving long-term outcomes.

Area of Science:

  • Neonatology
  • Pulmonology
  • Genetics

Background:

  • Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth.
  • Current definitions of BPD do not fully encompass its complex and evolving nature.
  • Persistent pulmonary issues are observed throughout the lifespan in individuals with BPD.

Purpose of the Study:

  • To analyze the evolution and limitations of current BPD definitions.
  • To propose a path forward for BPD research and treatment.
  • To emphasize the lifelong impact of BPD and related cardiopulmonary diseases.

Main Methods:

  • Review of longitudinal studies on BPD.
  • Analysis of current BPD diagnostic criteria.
  • Perspective on precision medicine approaches including deep phenotyping and multi-omic data integration.

Main Results:

  • Existing BPD definitions are inadequate for capturing disease heterogeneity.
  • Biomarkers for precise BPD endotyping and targeted therapies are still needed.
  • Collaborative data networks and longitudinal outcome measures are essential.

Conclusions:

  • Bronchopulmonary dysplasia (BPD) and related cardiopulmonary diseases are lifelong conditions.
  • Precision medicine approaches are vital for identifying BPD subtypes and guiding individualized care.
  • A shift in perspective is needed to view BPD beyond the neonatal intensive care unit (NICU) stay.

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