Related Experiment Video

Updated: Jan 13, 2026

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
07:01

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

1.9K

Exploring the mechanisms of serum miRNA in obesity-related kidney injury

Ran Zhang1, Jia-Lin Liu2

  • 1General Hospital of the Northern Theater Command (CN), Shenyang, China. 523231628@qq.com.

International Urology and Nephrology
|January 6, 2026
PubMed

Insights

Obesity significantly impacts kidney function through alterations in serum microRNAs (miRNAs). Understanding these miRNA changes offers potential for new diagnostic and therapeutic strategies for obesity-related kidney damage.

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Obesity is a global health crisis linked to chronic diseases, including kidney damage.
  • Obesity alters metabolic capacity, kidney structure, and function.
  • Serum microRNAs (miRNAs) are implicated in obesity and its complications, showing promise as biomarkers.

Purpose of the Study:

  • To review the impact of obesity on kidney function via serum miRNA alterations.
  • To analyze the underlying mechanisms of miRNA involvement in obesity-related kidney damage.
  • To summarize current research and identify future directions for clinical treatment.

Main Methods:

  • Literature review focusing on obesity, kidney function, and serum miRNAs.
  • Analysis of studies investigating miRNA regulation in obesity-induced nephropathy.
  • Synthesis of findings on miRNA roles in cellular processes affecting kidney health.

Main Results:

  • Serum miRNAs are significantly altered in obesity and correlate with kidney damage.
  • MiRNAs regulate key pathways in kidney injury, including proliferation, apoptosis, inflammation, and fibrosis.
  • Specific miRNA roles and their precise mechanisms in obesity-related kidney disease require further elucidation.

Conclusions:

  • Serum miRNAs represent crucial mediators in obesity-related kidney damage.
  • Further research into specific miRNA functions can lead to novel diagnostic biomarkers.
  • Targeting specific miRNAs may offer new therapeutic avenues for managing obesity-induced kidney disease.
Keywords:
Chronic illnessKidney injuryObesitySerum microRNA

More Related Videos

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

1.8K
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.3K

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
488
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
165
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
870
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
3.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.9K