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Primary Pericardial Mesothelioma: A Rare and Aggressive Malignancy - Case Report and Literature Review

Alves de Lima Agustina1, Carrero María Celeste1, Stutzbach Pablo Guillermo1

  • 1Instituto Cardiovascular de Buenos Aires, Clinical Cardiology, Buenos Aires, Blanco encalda, Argentina.

The American Journal of Cardiology
|January 6, 2026
PubMed

Insights

Primary pericardial mesothelioma (PPM) is a rare and aggressive cancer. This case report details a challenging diagnosis and poor prognosis, emphasizing the need for early detection and new treatments for this rare pericardial tumor.

Area of Science:

  • Oncology
  • Pathology
  • Cardiology

Background:

  • Primary tumors of the pericardium are exceptionally rare.
  • Primary pericardial mesothelioma (PPM) is the most common histological subtype.
  • PPM is an aggressive malignancy with a poor prognosis and short median survival.

Purpose of the Study:

  • To report a case of biphasic primary pericardial mesothelioma.
  • To highlight diagnostic challenges associated with PPM.
  • To underscore the need for improved management strategies for PPM.

Main Methods:

  • Case report of a 47-year-old woman.
  • Presentation with recurrent hemorrhagic pericardial effusions and hemodynamic compromise.
  • Histopathological analysis of resected pericardium confirming biphasic mesothelioma.

Main Results:

  • Diagnosis of biphasic pericardial mesothelioma, predominantly epithelioid subtype.
  • Delayed diagnosis due to nonspecific clinical presentation.
  • Patient experienced advanced stage disease at diagnosis.

Conclusions:

  • PPM presents significant diagnostic challenges.
  • Outcomes for PPM remain poor.
  • Heightened clinical suspicion, timely intervention, and further research are crucial for effective PPM management.
Keywords:
pericardial effusionpericardiumprimary pericardial mesothelioma

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