Related Experiment Video
Updated: Jan 13, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited
Malka Cohen-Armon1, Menahem Segal2
1Gray Faculty of Medicine and Health Sciences & Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. marmon@tauex.tau.ac.il.
None:
The therapeutic potential of PARP inhibitors in neurodegenerative diseases of the central nervous system is widely accepted. This prevailing concept is challenged by more recent findings, unveiling the role of PARP1 activity in synaptic long-term potentiation, synaptic plasticity and long-term memory. So, PARP1 inhibition, though intended to prevent memory deterioration, actually interferes with stimulation-induced synaptic plasticity and long-term memory. On the other hand, PARP inhibitors could be useful for preventing mental disorders associated with memory retrieval.
Related Concept Videos
Long-term Potentiation
Long-term Potentiation
Hebbian LTP
LTP can occur when...
Postsynaptic Potential (PSP)
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
Integration of Synaptic Events
Synaptic Signaling
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Synaptic Signaling

