Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulatory microRNA signature distinguishing rheumatoid arthritis and psoriatic arthritis.

Rheumatology (Oxford, England)·2026
Same author

JAK/STAT inhibition reprograms T cell activation and metabolism in inflammatory arthritis patients.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same author

Chasing the target: reports from the Advances in Targeted Therapies meeting, 2025.

Annals of the rheumatic diseases·2026
Same author

RA and PsA synovial tissue single-cell analysis demonstrates differential fibroblast populations with distinct phenotypes and functional capacities.

Annals of the rheumatic diseases·2026
Same author

Fibroblasts neurotrophin signaling sustains pathological vascular maturation in rheumatoid arthritis.

bioRxiv : the preprint server for biology·2026
Same author

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.

Nature immunology·2026

Related Experiment Video

Updated: Jan 13, 2026

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

10.1K

Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis.

Megan M Hanlon1, Ursula Fearon2, Ellen M Gravallese1

  • 1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.

European Journal of Immunology
|January 6, 2026
PubMed
Summary
This summary is machine-generated.

Synovial tissue macrophages are key in rheumatoid arthritis (RA) pathogenesis. Understanding their diverse subsets and roles is vital for developing new RA therapies targeting these immune cells.

Keywords:
macrophagesmetabolismrheumatoid arthritissynoviumtissue resident

More Related Videos

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

20.8K
In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
07:15

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Published on: October 20, 2013

9.7K

Related Experiment Videos

Last Updated: Jan 13, 2026

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

10.1K
Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

20.8K
In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
07:15

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Published on: October 20, 2013

9.7K

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • Synovial tissue macrophages are central to rheumatoid arthritis (RA) pathogenesis.
  • The specific roles of different macrophage subsets in RA inflammation are not fully understood.
  • Recent advances enable detailed study of these cells.

Purpose of the Study:

  • To review recent findings on synovial tissue macrophages in RA.
  • To explore their ontogeny, metabolism, and interactions within the synovium.
  • To understand how macrophages influence RA and how the RA environment affects them.

Main Methods:

  • Review of current literature and recent technological advances.
  • Analysis of single-cell technologies revealing myeloid subsets in synovium.
  • Examination of macrophage development, function, and spatial distribution.

Main Results:

  • Synovial tissue harbors diverse macrophage subsets with distinct characteristics.
  • Macrophages significantly shape the inflammatory environment in RA.
  • The local synovial environment influences macrophage development.

Conclusions:

  • A comprehensive understanding of synovial macrophages is crucial for RA.
  • Targeting specific macrophage subsets may offer novel therapeutic strategies for RA.
  • Further research into macrophage ontogeny and function is warranted.