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Pylorus Endoluminal Functional Luminal Imaging Probe Measurements in Children Are Determined by Age and Are

Jaime Chan1, Noeni Austin1, Miri Taneichi1

  • 1Faculty of Life Sciences and Medicine; King's College London, London, UK.

Journal of Neurogastroenterology and Motility
|January 6, 2026
PubMed

Insights

Pediatric pylorus functional luminal imaging probe (EndoFLIP) values are influenced by age, not weight, and correlate with gastric emptying symptoms. Establishing age-specific pediatric protocols is crucial for accurate assessment.

Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Medical Imaging

Background:

  • The pylorus plays a critical role in gastric emptying and is implicated in delayed gastric drainage symptoms.
  • Endoluminal functional luminal imaging probe (EndoFLIP) can predict treatment response for pylorus-directed therapy in children and adults.
  • Established normal pylorus EndoFLIP values exist for adults but are lacking for pediatric populations.

Purpose of the Study:

  • To assess the impact of age on pediatric pyloric EndoFLIP values.
  • To determine if weight influences pediatric pyloric EndoFLIP measurements.
  • To establish correlations between pediatric pyloric EndoFLIP values and symptoms of impaired gastric emptying.

Main Methods:

  • Retrospective review of pediatric pylorus EndoFLIP procedures conducted at Evelina London Children's Hospital.
  • Data collected from July 2022 to March 2025.
  • Analysis of 169 EndoFLIP measurements from 29 pediatric patients.

Main Results:

  • Pediatric pylorus EndoFLIP values demonstrated significant differences across age ranges (0-4, 4-8, >8 years) but showed no correlation with weight.
  • Abdominal distension correlated with distensibility and pressure at 40 mL balloon volume.
  • Gastric feeding intolerance and post-feeding pain correlated with high balloon pressure.

Conclusions:

  • Pediatric pylorus EndoFLIP values are age-dependent, not weight-dependent, and correlate with impaired gastric emptying symptoms.
  • Adult normal values for pylorus EndoFLIP are not applicable to children.
  • A distinct pediatric protocol for pylorus EndoFLIP is necessary for accurate clinical application.
Abstract

Keywords:
ChildEndoFLIPPylorus

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