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Updated: Jan 13, 2026

The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders
Published on: August 25, 2022
Mpox therapeutics in the post-STOMP/PALM era
Katherine Promer1, Sara Bt Brenner, Lily Ostrer
1Department of Medicine, Division of Infectious Diseases and Global Public Health University of California San Diego, San Diego, California, USA.
Purpose Of Review:
This article reviews the evidence behind mpox antiviral therapies which are clinically available and/or or under clinical investigation. For much of the mpox epidemic, tecovirimat has been used compassionately but there is no evidence of its clinical efficacy.
Recent Findings:
Multiple phase 3 placebo-controlled trials have failed to demonstrate clinical efficacy of tecovirimat in the treatment of mpox.
Summary:
This article summarizes the evidence behind current treatment recommendations including tecovirimat, brincidofovir, cidofovir, trifluridine, and VIGIV, as well as other investigational treatments.
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