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Hypertension guidelines need to be patient oriented

Nayanatara Nadeesha Tantirige1, Joanna M Gray1, Ian B Wilkinson2

  • 1Cambridge University Hospitals NHS Foundation Trust, Cambridge.

Current Opinion in Nephrology and Hypertension
|January 6, 2026
PubMed

Insights

Personalised hypertension treatment improves blood pressure control by considering individual factors like genetics and ethnicity. Future guidelines should incorporate these personalised approaches for better patient outcomes.

Area of Science:

  • Cardiology
  • Pharmacogenomics
  • Clinical Hypertension

Background:

  • Hypertension management traditionally uses a one-size-fits-all approach.
  • Growing evidence suggests personalized treatment improves blood pressure control.
  • Inter-individual variability in treatment response necessitates tailored strategies.

Purpose of the Study:

  • To review current evidence supporting individualized hypertension treatment.
  • To explore the application of personalized medicine in future hypertension guidelines.
  • To examine variability in blood pressure control and treatment response.

Main Methods:

  • Literature review of recent studies on hypertension treatment personalization.
  • Analysis of factors influencing inter-individual variability in drug response.
  • Examination of genetic data, including genome-wide association studies (GWAS) and polygenic risk scores (PRS).

Main Results:

  • Significant inter-individual variability exists in responses to antihypertensive medications.
  • Factors like ethnicity, sex, age, BMI, and genetics influence blood pressure and cardiovascular risk.
  • Emerging genetic data and polygenic risk scores show promise for targeted pharmacotherapy.

Conclusions:

  • Personalized hypertension care is a rapidly developing field.
  • Clinical guidelines need refinement to better address individual differences in blood pressure and treatment response.
  • Tailoring hypertension treatment based on individual patient characteristics is crucial for optimal outcomes.
Abstract

Keywords:
clinical guidelineshypertensionpersonalised medicine

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