Related Experiment Video
Updated: Jan 13, 2026
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
Engineered polypeptide cascade-release platform restores macrophage plasticity for accelerated diabetic wound healing
Hao Xia1, Qi Tang1, Zhen Chen1
1Research Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
This study introduces a novel biomaterial (G3D-Pmet25@PDA) that reprograms the immune microenvironment in diabetic wounds. This programmed therapy accelerates healing by clearing immune cells and promoting tissue regeneration.
Area of Science:
- Biomaterials Science
- Immunology
- Regenerative Medicine
Background:
- Diabetic wound healing is impaired by persistent inflammation due to immune cell dysregulation.
- Coordinated immune niche regulation is essential for effective tissue regeneration in diabetic wounds.
Purpose of the Study:
- To develop a programmed therapeutic strategy to reprogram the immune niche in diabetic wounds.
- To investigate the potential of a novel dendrimeric polypeptide biomaterial for enhancing diabetic wound repair.
Main Methods:
- Development of arginine-lysine-methionine third-generation dendrimeric polypeptides with dopamine-coated surfaces containing ferrous ions (G3D-Pmet25@PDA).
- Utilized near-infrared (NIR) laser irradiation to trigger ferrous ion release and reactive oxygen species (ROS) to induce hydrophilic transition of methionine chains.
- Assessed the biomaterial's effect on immune cell clearance, energy metabolism reprogramming, nitric oxide release, and angiogenesis in the context of diabetic wound healing.
Main Results:
- G3D-Pmet25@PDA demonstrated a core-shell structure enabling triggered release of ferrous ions and arginine.
- NIR laser irradiation initiated immune cell clearance and reprogrammed immune cell metabolism, alleviating inflammation.
- Sustained nitric oxide release promoted angiogenesis, further contributing to accelerated tissue regeneration.
Conclusions:
- The developed programmed therapeutic strategy effectively reshapes the immune niche to promote diabetic wound healing.
- G3D-Pmet25@PDA shows promise as a novel immunomodulatory biomaterial for treating complex wounds.
- Findings offer new insights into immune system coordination for diabetic wound repair and regenerative strategies.
