Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

882
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
882
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

631
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
631
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

1.9K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
1.9K
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

449
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
449
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

438
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
438
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

945
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
945

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Joint association of low bone mass and reduced relative handgrip strength with fragility fracture risk in adults aged 50-59 years: A cross-sectional study from NHANES 2013-2014.

Medicine·2026
Same author

Integrative Transcriptomic Analysis and Single-Cell Validation Identify a Six-Hub-Gene Signature Converging on Inflammatory Signaling in Osteoarthritis.

Genes·2026
Same author

Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis.

GeroScience·2026
Same author

Achieving Superior Mechanical Properties in CoCrNiCuFe High-Entropy Alloys via Synergistic Design of Composition and Gradient Nanostructure.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Clinical, social, and motility factors influencing transanal irrigation response in pediatric patients.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Phenolic Copigment Enhanced Anthocyanin Stability and Color Intensity of Frozen Red Huajiao (<i>Zanthoxylum bungeanum</i> Maxim.) Fruit.

Foods (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 13, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K

Decoding ulcerative colitis pathogenesis through transcriptomics: from dysregulated gene networks to targeted

Xiang Zhu1,2, Yujie Yang3, Yi Zhu1

  • 1The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China.

Journal of Translational Autoimmunity
|January 6, 2026
PubMed
Summary

This study identifies key genes like HCLS1, ITGA4, and PDGFRB involved in ulcerative colitis (UC) inflammation. These findings advance understanding of UC pathogenesis and potential therapeutic targets for this chronic inflammatory bowel disease.

Keywords:
Differentially expressed genesImmune cell infiltrationMendelian randomizationMicroarray dataUlcerative colitiseQTL analysis

More Related Videos

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.7K
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.7K

Related Experiment Videos

Last Updated: Jan 13, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.7K
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.7K

Area of Science:

  • Genomics
  • Immunology
  • Gastroenterology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease with increasing incidence and malignant transformation risk.
  • Current UC treatments face challenges due to disease heterogeneity, limited targeted therapies, and unclear pathogenesis.
  • Identifying novel therapeutic targets and understanding genetic factors are crucial for advancing UC precision medicine.

Purpose of the Study:

  • To identify novel therapeutic targets for ulcerative colitis (UC).
  • To elucidate genetic factors associated with UC development.
  • To advance precision medicine strategies for UC treatment.

Main Methods:

  • Differential gene expression analysis on independent UC datasets (GEO database).
  • eQTL-MR analysis to identify UC-related gene expression loci, intersected with differential expression data.
  • Protein-protein interaction network construction, hub gene identification, and functional enrichment analyses (GSEA, GO, KEGG).

Main Results:

  • Twenty intersecting genes were identified, including HCLS1, ITGA4, and PDGFRB, involved in immune response and epithelial barrier regulation.
  • CIBERSORT analysis revealed distinct immune cell distributions in UC and their association with identified genes.
  • Gene Set Enrichment Analysis indicated that high expression of HCLS1, ITGA4, and PDGFRB correlates with inflammatory cell recruitment and immune signaling amplification.

Conclusions:

  • HCLS1, ITGA4, and PDGFRB are core modules in T/B cell activation, macrophage recruitment, and extracellular matrix responses in UC.
  • These genes interact with upregulated genes to amplify inflammation, counteracting metabolic pathways.
  • These findings contribute to understanding the molecular basis of the inflammatory and metabolic phenotype in ulcerative colitis.