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Updated: Jul 13, 2026
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Oral Squamous Cell Carcinoma in a Patient with Myelodysplastic Syndrome: Report of a Case and Literature Review
Parmiss Omidsalar1, Monir Moradzadeh Khiavi2, Nafiseh Sheykhbahaei3,4
1Department of Oral & Maxillofacial Medicine, School of Dentistry, Bushehr University of Medical Sciences, Bushehr, Iran.
Abstract:
Myelodysplastic syndrome (MDS) is a bone marrow clonal stem cell disorder characterized by the inability of immature blood cells to mature. Oral squamous cell carcinoma (OSCC) has not been previously reported in MDS patients without underlying diseases. We present a case of poorly differentiated OSCC in a 27-year-old patient with MDS. A literature review revealed 11 case reports about solid tumors in different organs of MDS patients. Among these, 5 articles reported head and neck carcinoma but none of them reported oral cancer in MDS patients. MDS predisposes patients to hematopoietic and non-hematopoietic malignancies. The oral cavity is one of the critical sites that needs to be examined periodically and regularly in MDS patients to detect OSCC in its early stages.
