PaedIatric caNcelation ratEs And PerioPerative clinicaL Evaluation (PINEAPPLE): A UK Prospective Multi-Center

Tom Bennett1, Hannah Lewis2, Catherine Riley3

  • 1University Hospital Southampton, Southampton, UK.

Paediatric Anaesthesia
|January 6, 2026
PubMed

Insights

Pediatric preassessment significantly reduced patient anxiety before general anesthesia, though it did not impact cancelation rates. Standardizing preassessment services nationally is recommended to maximize benefits and improve child surgical outcomes.

Area of Science:

  • Pediatric Anesthesiology
  • Perioperative Medicine
  • Healthcare Quality Improvement

Background:

  • Pediatric preassessment is a recommended practice for children undergoing general anesthesia.
  • It holds potential for enhancing patient safety and organizational quality outcomes.
  • This study investigates the current state and impact of preassessment in pediatric anesthesia.

Purpose of the Study:

  • To determine the proportion of children receiving preassessment before general anesthesia.
  • To analyze the formats of preassessment delivery.
  • To evaluate the impact of preassessment on outcomes like on-the-day cancelations and patient anxiety.

Main Methods:

  • A multi-center prospective observational cohort study was conducted in the UK.
  • Data were collected from 96 hospitals involving 6818 children aged 1-16 years.
  • Participants were recruited via the Pediatric Anesthetic Trainee Research Network.

Main Results:

  • 60.1% of children (4082) received preassessment, with significant variation in delivery methods, mostly nurse-led.
  • Preassessment was associated with a significant reduction in perioperative anxiety (12.0% vs. 16.5%, p < 0.001).
  • No statistically significant difference in overall cancelation rates was observed; common reasons included intercurrent illness and anxiety.

Conclusions:

  • Reducing patient anxiety through preassessment can improve surgical outcomes.
  • Screening calls before surgery may prevent cancelations due to illness.
  • National standardization of pediatric preassessment is needed to optimize its benefits.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
201
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
239
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
249
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
185