Related Experiment Video

Updated: Jan 13, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

A bibliometric analysis of 2000-2024 on interventional therapy for liver cancer and tumor immune microenvironment

Siqin Liang¹, Ming Li², Zhiliang Xu¹

¹Department of Hepatobiliary Tumor Surgery, Department of Interventional Therapy, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research Center for Cancer, Nanchang, China; Jiangxi Key Laboratory of Translational Cancer Research, Jiangxi Cancer Hospital of Nanchang University, Nanchang, China; Gannan Medical University, Ganzhou, China.

Chinese Clinical Oncology

|January 6, 2026

Abstract

Background:

In recent years, the tumor immune microenvironment (TIME) has been gradually emphasized in liver cancer interventional therapy. The present study aimed to evaluate the current research hotspots and developmental trends of TIME from the perspective of bibliometrics.

Methods:

Publications related to interventional therapy, liver cancer, and TIME were searched on the Web of Science (WOS) Core Collection database for the years 2000-2024, and bibliometric analyses were performed using VOSviewer, CiteSpace, and R "Bibliometrix".

Results:

A bibliometric analysis was conducted on the TIME in liver cancer interventional therapy using data from 2000-2024. The study included 277 articles from 21 regions/countries, with China and the USA leading. The number of articles is increasing annually. Fudan University and Huazhong University of Science and Technology are major research institutions. The Journal of Hepatocellular Carcinoma is the most popular journal, while Hepatology is the most cited. Zheng Chuansheng published the most papers, and Llovet was the most co-cited. Research topics include the mechanism of the TIME in interventional therapy and novel therapies. Emerging hotspots are "Immunotargeted inhibition", "tumor microenvironment", and "immunotherapy".

Conclusions:

This is the first comprehensive bibliometric study in this field, providing insights into research trends and new directions.

Keywords:

Liver cancer Web of Science (WOS)bibliometric analysis interventional therapy tumor immune microenvironment (TIME)

More Related Videos

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Articles linked to this work by shared authors, journal, and citation graph.

Solution-solid-solid mechanism: superionic conductors catalyze nanowire growth.

Nano letters·2013

Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX.

Liver international : official journal of the International Association for the Study of the Liver·2013

Low-voltage switching of crease patterns on hydrogel surfaces.

Advanced materials (Deerfield Beach, Fla.)·2013

Long non-coding RNAs and prostate cancer.

Journal of nanoscience and nanotechnology·2013

Self-assembled graphene quantum dots induced by cytochrome c: a novel biosensor for trypsin with remarkable fluorescence enhancement.

Nanoscale·2013

Relationship between glutathione S-transferase P1 (GSTP1), X-ray repair cross complementing group 1 (XRCC1) and 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene polymorphisms and response to chemotherapy in advanced gastric cancer.

Onkologie·2013

See all related articles