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The Impact of p16 Status on Survival Within Non-Oropharyngeal Head and Neck Squamous Cell Carcinoma
David Ahmadian1, Charles J Gallego1, Camila Hurtado1
1Head & Neck Surgery, University of Arizona Department of Otolaryngology, United States.
Background:
HPV-mediated oropharyngeal cancers have shown improved oncologic outcomes compared to traditional head and neck squamous cell carcinoma (HNSCC). P16, a surrogate marker for HPV, is also overexpressed in non-oropharyngeal squamous cell carcinoma (non-OPSCC), but its clinical impact remains unclear. This study evaluates the effect of p16 status in non-OPSCC.
Methods:
A retrospective chart review of non-OPSCC patients from January 2017 to November 2023 was conducted. Demographics, clinical data, and p16 expression were analyzed. Survival and recurrence rates were compared using Cox regression and Kaplan-Meier with log-rank testing.
Results:
A total of 197 patients with non-OPSCC were included, most commonly in the oral cavity (55.3%). P16+ tumors were found in 21.8% of cases. Median follow-up length was similar between groups (p = 0.724). Tumor recurrence rates were similar (p = 0.377), and p16+ status did not significantly impact survival.
Conclusions:
P16 overexpression in non-OPSCC does not confer a significant survival advantage or reduced recurrence.
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