Related Experiment Video

Updated: Jan 13, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.3K

The Persistent Respiratory Impact of Respiratory Syncytial Virus (RSV) Bronchiolitis in Infants

Elif Çelik1, Pınar Uysal2

  • 1Department of Pediatrics, Aydin Adnan Menderes University Faculty of Medicine, Aydin, Türkiye.

Pediatric Pulmonology
|January 6, 2026
PubMed

Insights

Infants hospitalized with respiratory syncytial virus (RSV) bronchiolitis show persistent expiratory airway obstruction, even after recovery. Lung function impairment in children with RSV bronchiolitis requires long-term monitoring.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Viral Infections
  • Infant Lung Health

Background:

  • Infant respiratory syncytial virus (RSV) bronchiolitis can lead to long-term respiratory issues like asthma.
  • Limited data exists on infant lung function using tidal breath analysis post-bronchiolitis.

Purpose of the Study:

  • Assess infant lung function via tidal breath analysis after RSV bronchiolitis.
  • Compare lung function during acute illness versus 2 months post-recovery.
  • Evaluate the impact of bronchiolitis severity on lung function outcomes.

Main Methods:

  • Prospective study of 78 infants (1-12 months): 39 with RSV bronchiolitis, 39 healthy controls.
  • Tidal breath analysis performed during hospitalization and 2 months after recovery.
  • Comparison between RSV patients and controls, and across disease severity subgroups.

Main Results:

  • Infants with RSV bronchiolitis had significantly lower time to peak tidal expiratory flow to expiratory time (tPTEF/tE) ratio compared to controls.
  • This reduction in tPTEF/tE persisted at 2-month follow-up, with no significant improvement.
  • Severe RSV bronchiolitis cases showed lower tPTEF and tPTEF/tE values than mild/moderate cases.

Conclusions:

  • Expiratory airway obstruction may persist in infants after RSV bronchiolitis, despite clinical recovery.
  • Lack of improvement in tidal breathing parameters (tPTEF, tPTEF/tE) indicates a need for long-term follow-up.
  • Increased disease severity correlates with more persistent lung function impairment, emphasizing early detection and prevention.
Abstract

More Related Videos

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.4K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.0K

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
3.0K
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
64.1K
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
448
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.3K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.0K
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
821