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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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  1. Home
  2. Long-term Neurological Health Of The Term Offspring Born Via Cesarean Section For Non-reassuring Fetal Monitoring.
  1. Home
  2. Long-term Neurological Health Of The Term Offspring Born Via Cesarean Section For Non-reassuring Fetal Monitoring.

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Long-term neurological health of the term offspring born via cesarean section for non-reassuring fetal monitoring.

Gil Gutvirtz1, Gali Pariente2, Tamar Wainstock3

  • 1Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, 151 Izak Rager Ave, 84101, Beer-Sheva, Israel. Gilgut@bgu.ac.il.

Archives of Gynecology and Obstetrics
|January 6, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Cesarean delivery (CD) for non-reassuring fetal heart rate (NRFHR) did not increase long-term neurological morbidity in children. Prompt intervention during labor may prevent adverse neurological outcomes, regardless of delivery method.

Keywords:
Cesarean deliveryFetal monitoringIntrapartumLong-term follow-upNeurological morbidityPerinatal outcomesTerm delivery

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Neurology
  • Perinatal Medicine

Background:

  • Intrapartum fetal heart rate (FHR) monitoring may reduce intrapartum death.
  • Evidence linking FHR monitoring to reduced long-term neurological impairment is limited.
  • Cesarean delivery (CD) for non-reassuring FHR (NRFHR) is common, but its impact on offspring neurological outcomes requires clarification.

Purpose of the Study:

  • To evaluate long-term neurological morbidity in offspring born via CD for NRFHR.
  • To compare neurological outcomes between CD for NRFHR and CD for non-progressive labor (NPL).

Main Methods:

  • Population-based cohort analysis of term singleton births.
  • Comparison of CD for NRFHR versus CD for NPL.
  • Assessment of neurological morbidity up to 18 years of age.
  • Kaplan-Meier survival curves and generalized estimating equations (GEE) for analysis.
  • Main Results:

    • 14,333 term singleton CDs met inclusion criteria (59.0% for NRFHR, 41.0% for NPL).
    • Total long-term neurological morbidity rates were comparable between NRFHR and NPL groups.
    • NRFHR leading to CD was not a significant risk factor for offspring long-term neurological morbidity (aHR 1.87, 95% CI 0.74-4.72).

    Conclusions:

    • Intrapartum NRFHR leading to CD does not predict long-term neurological morbidity.
    • Prompt intervention during labor may mitigate neurological risks associated with NRFHR.
    • Further research may explore the specific mechanisms of prompt intervention in preventing neurological impairment.