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Updated: Jan 13, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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ROR1 protein: a pseudokinase at the crossroads of cancer progression and therapy

Shradheya R R Gupta1, Rashmi Rameshwari2, Indrakant Kumar Singh3,4,5

  • 1Department of Biotechnology, School of Engineering and Technology (SET), Manav Rachna International Institute of Research and Studies (MRIIRS), Faridabad, Haryana, 121004, India.

Molecular Biology Reports
|January 6, 2026
PubMed

Insights

Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) is a pseudokinase crucial in cancer. Targeting ROR1 offers a promising strategy for developing novel anti-cancer therapies against various malignancies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Pseudokinases regulate cellular processes despite lacking enzymatic activity.
  • Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) is a pseudokinase implicated in cancer biology.
  • ROR1 is aberrantly expressed in numerous cancers but not in normal adult tissues.

Purpose of the Study:

  • To provide an in-depth analysis of ROR1's structural and functional characteristics.
  • To explore ROR1's interactions with oncogenic signaling pathways and its role in tumor progression.
  • To review current and emerging therapeutic strategies targeting ROR1.

Main Methods:

  • Literature review and analysis of ROR1's role in cancer.
  • Examination of ROR1's structural and functional attributes.
  • Assessment of therapeutic strategies including antibodies, ADCs, CAR T-cell therapy, and small-molecule inhibitors.

Main Results:

  • ROR1 drives tumor survival, metastasis, therapy resistance, and stemness.
  • ROR1 interacts with key oncogenic signaling pathways.
  • Various therapeutic modalities targeting ROR1 show clinical potential.

Conclusions:

  • ROR1 is a significant therapeutic target in oncology due to its oncogenic roles and unique expression.
  • Developing effective anti-cancer strategies requires understanding ROR1's mechanisms and overcoming therapeutic challenges.
  • Targeting ROR1 holds promise for treating hematologic cancers and solid tumors.
Keywords:
CancerPseudokinaseROR1Wnt5a

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