Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Supplementation with long-chain polyunsaturated fatty acids to extremely preterm infants associates with development of the intestinal microbiota.

Pediatric research·2026

Same author

Academic achievement in children born extremely preterm: a cohort study.

Archives of disease in childhood. Fetal and neonatal edition·2026

Same author

Developmental Trends in Serum Iron, Transferrin, and Transferrin Saturation From Birth to 12 Months.

Acta paediatrica (Oslo, Norway : 1992)·2026

Same author

Long-Term Societal Costs After Births Before 24 Weeks of Gestation in Sweden.

Acta paediatrica (Oslo, Norway : 1992)·2026

Same author

Low serum sphingosine-1-phospate and its chaperone ApoM associate with retinopathy of prematurity.

Journal of lipid research·2026

Same author

Neurodevelopmental Outcomes 12 Years After Extremely Preterm Birth in Sweden.

Pediatrics·2026

Search research articles

Related Experiment Video

Updated: Jan 13, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Acoustofluidic Plasmapheresis System Designed for Ultralow Blood Volume Applications.

Amal Nath¹, Sara Marie Larsson^2,3, Andreas Lenshof¹

¹Department of Biomedical Engineering, Lund University, Lund SE-223 63, Sweden.

Analytical Chemistry

|January 6, 2026

Summary

This study introduces an acoustofluidic plasmapheresis system for neonates, achieving high-purity plasma separation from minimal blood volumes. The innovative device supports critical care by enabling continuous, closed-loop plasma generation for infants.

More Related Videos

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

Related Experiment Videos

Last Updated: Jan 13, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

Area of Science:

Biomedical Engineering
Microfluidics
Acoustics

Background:

Neonatal intensive care requires precise management of extremely low blood volumes.
Existing plasma separation methods often demand larger sample volumes, posing risks for neonates.
There is a need for efficient, in-line plasma separation systems suitable for point-of-care neonatal applications.

Purpose of the Study:

To develop and validate an integrated acoustofluidic plasmapheresis system for ultralow blood volume applications, specifically in neonatal care.
To enable continuous, closed-loop plasma separation with minimal sample loss for neonates.
To achieve high plasma purity and throughput while maintaining system robustness.

Main Methods:

Integration of a two-stage acoustophoresis chip with microperistaltic pumps and PDMS-based flow pulsation dampeners.
Acoustic separation of whole blood into cell-free plasma and a returnable cell fraction.
Validation of plasma quality through hemolysis and residual cellular content quantification.
Testing system robustness across a range of hematocrit levels (up to 50%).

Main Results:

The system achieved a plasma generation rate of 27.5 μL/min with approximately 100% cell removal.
Demonstrated superior plasma purity, throughput, and minimal sample volume compared to previous microfluidic approaches.
Validated plasma quality and system robustness, performing effectively at hematocrit levels relevant to neonates.
Achieved the fastest generation of clinical-quality undiluted plasma with the lowest blood volume requirement.

Conclusions:

The developed acoustofluidic plasmapheresis system is highly suitable for point-of-care integration in neonatal intensive care units.
It offers a significant advancement for managing ultralow blood volumes in neonatal patients.
The system provides a safe, efficient, and effective solution for plasma separation in critical neonatal care settings.