Association between obstructive sleep apnea and metabolic profiles across sleep stages in pediatrics
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric obstructive sleep apnea (OSA) is linked to metabolic changes during all sleep stages. Oxygen desaturation index (ODI) during REM sleep showed significant metabolic effects, impacting lipid profiles and triglycerides.
Area Of Science
- Pediatric Sleep Medicine
- Pediatric Endocrinology
- Metabolic Health
Background
- Obstructive sleep apnea (OSA) is increasingly recognized in children.
- Metabolic dysregulation is a potential consequence of OSA.
- Understanding sleep stage-specific metabolic impacts is crucial for pediatric health.
Purpose Of The Study
- To investigate the relationship between metabolic profiles and OSA in children.
- To differentiate the metabolic associations during REM and NREM sleep stages.
- To evaluate the role of obstructive apnea hypopnea index (OAHI) and oxygen desaturation index (ODI) in pediatric metabolic health.
Main Methods
- Overnight polysomnography (PSG) and biochemical tests were performed on 514 children.
- Obstructive apnea hypopnea indices (OAHI) and oxygen desaturation indices (ODI) were calculated for total sleep time (TST), REM, and NREM sleep.
- Multivariate analyses assessed associations between sleep variables and metabolic parameters, adjusting for BMI z-score.
Main Results
- OSA severity, defined by OAHI, was associated with significant differences in lipid profiles (HDL-C, LDL-C), triglycerides (TG), and other metabolic markers during TST and NREM sleep.
- Both OAHI and ODI during REM and NREM sleep were independently linked to various metabolic parameters.
- ODI during REM sleep showed stronger associations with lipid profiles, TG, and total cholesterol (TCH) compared to NREM sleep.
Conclusions
- In pediatric OSA, OAHI correlates with metabolic alterations across all sleep stages.
- ODI demonstrates more pronounced metabolic effects during REM sleep.
- Specific metabolic parameters like TG, LDL-C, and TCH are particularly influenced by ODI severity during REM sleep in children with OSA.
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