Related Experiment Video

Updated: Jan 13, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.5K

Association between obstructive sleep apnea and metabolic profiles across sleep stages in pediatrics

Yiling Wan1, Xiaoyi Wang1, Xianshan Hu2

  • 1Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, China.

Sleep Medicine
|January 6, 2026
PubMed

Insights

Pediatric obstructive sleep apnea (OSA) is linked to metabolic changes during all sleep stages. Oxygen desaturation index (ODI) during REM sleep showed significant metabolic effects, impacting lipid profiles and triglycerides.

Area of Science:

  • Pediatric Sleep Medicine
  • Pediatric Endocrinology
  • Metabolic Health

Background:

  • Obstructive sleep apnea (OSA) is increasingly recognized in children.
  • Metabolic dysregulation is a potential consequence of OSA.
  • Understanding sleep stage-specific metabolic impacts is crucial for pediatric health.

Purpose of the Study:

  • To investigate the relationship between metabolic profiles and OSA in children.
  • To differentiate the metabolic associations during REM and NREM sleep stages.
  • To evaluate the role of obstructive apnea hypopnea index (OAHI) and oxygen desaturation index (ODI) in pediatric metabolic health.

Main Methods:

  • Overnight polysomnography (PSG) and biochemical tests were performed on 514 children.
  • Obstructive apnea hypopnea indices (OAHI) and oxygen desaturation indices (ODI) were calculated for total sleep time (TST), REM, and NREM sleep.
  • Multivariate analyses assessed associations between sleep variables and metabolic parameters, adjusting for BMI z-score.

Main Results:

  • OSA severity, defined by OAHI, was associated with significant differences in lipid profiles (HDL-C, LDL-C), triglycerides (TG), and other metabolic markers during TST and NREM sleep.
  • Both OAHI and ODI during REM and NREM sleep were independently linked to various metabolic parameters.
  • ODI during REM sleep showed stronger associations with lipid profiles, TG, and total cholesterol (TCH) compared to NREM sleep.

Conclusions:

  • In pediatric OSA, OAHI correlates with metabolic alterations across all sleep stages.
  • ODI demonstrates more pronounced metabolic effects during REM sleep.
  • Specific metabolic parameters like TG, LDL-C, and TCH are particularly influenced by ODI severity during REM sleep in children with OSA.
Abstract

Keywords:
DyslipidemiaLipid metabolismMetabolic profilesNon-rapid eye movementObstructive sleep apneaRapid eye movement

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K
Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.7K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
469
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
189
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
165
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
240
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
235
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.7K