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Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Signaling pathways and targeted interventions for precancers.

Jin Yang1, Shimeng Wang1,2, Xin Li1

  • 1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Sichuan, PR China.

Signal Transduction and Targeted Therapy
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PubMed
Summary

Early intervention in precancer holds promise for reducing cancer. This review explores precancer biology, signaling pathways, and proposes a "soil degeneration" hypothesis for dual-window intervention strategies.

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Precancers are tissues with oncogenic potential, crucial for early cancer intervention.
  • Understanding precancer biology is key to reducing cancer morbidity and mortality.
  • Current knowledge of signaling networks in precancer progression is limited, hindering targeted therapies.

Purpose of the Study:

  • To synthesize the evolution of precancer research.
  • To elucidate mechanisms of precancer progression, including epithelial and microenvironmental changes.
  • To catalog dysregulated signaling pathways and assess their therapeutic potential.

Main Methods:

  • Literature review synthesizing historical, mechanistic, and signaling network data on precancer.
  • Analysis of over 10 key signaling pathways (e.g., TGF-β, p53, Wnt, PI3K, MAPK).
  • Integration of emerging evidence on the role of the tumor microenvironment.

Main Results:

  • Identified over 10 signaling pathways driving malignant transformation.
  • Synthesized evidence supporting the dominance of microenvironmental factors in precancer progression.
  • Proposed the "soil degeneration" hypothesis, emphasizing microenvironment's role.

Conclusions:

  • Dual-window intervention is necessary, targeting both epithelial malignancy and stromal degeneration.
  • Precision intervention frameworks, including biomarker-guided risk assessment, are advocated.
  • Remodeling the precancer microenvironment is crucial for redefining intervention in the molecularly targeted era.