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Updated: Jan 13, 2026

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
Published on: April 27, 2018
Breaking barriers in prostate cancer: the mRNA vaccine breakthrough and what comes next
Rayan Rajabi1, Somayeh Vafaei2, Fatemeh Afrashteh3
1Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
Prostate cancer (PC) treatment is evolving beyond conventional therapies. This review explores mRNA-based vaccines as a promising immunotherapy. We discuss their mechanism of action, advantages in production and safety, and results from early clinical trials (e.g., CV9103/4). Key challenges like antigen selection and the immunosuppressive tumor microenvironment are addressed, alongside advancements in lipid nanoparticle delivery and combinatorial strategies with checkpoint inhibitors to enhance efficacy and usher in personalized PC treatment.
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