Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Conservative Site-specific Recombination and Phase Variation

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Fluoroether Co-Solvent Engineering Interfacial and Solvation Dynamics for Durable Lithium-Oxygen Batteries.

Angewandte Chemie (International ed. in English)·2026

Same author

Polymorphic phase engineering of flat plasmons in a correlated oxide.

Nanoscale·2026

Same author

Helicity-selective and spectrally tunable chiral thermal emissions.

Nature communications·2026

Same author

Monolayer MoS<sub>2</sub> Optoelectronic Synapses on Fe:LiNbO<sub>3</sub> Substrate with Photovoltaic Control for Neuromorphic Applications.

ACS applied materials & interfaces·2026

Same author

Laser-written glass tablets can preserve data for millennia.

Nature·2026

Same author

Induced fit growth of Ga-based semiconductor thin films for brain-inspired electronics and optoelectronics.

Light, science & applications·2026

Same journal

Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice.

Nature communications·2026

Same journal

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

Nature communications·2026

Same journal

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.

Nature communications·2026

Same journal

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026

Same journal

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.

Nature communications·2026

Same journal

Proton shuttling at electrochemical interfaces under alkaline hydrogen evolution.

Nature communications·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 13, 2026

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

Reconfigurable all-solid-state topological lasing at arbitrary sites.

Bo Wu¹, Jinting Ding², Wenchao Yan¹

¹School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan, China.

Nature Communications

|January 6, 2026

Summary

This summary is machine-generated.

Researchers developed a reconfigurable topological laser using a solid-state laser crystal. This new design overcomes limitations of previous topological lasers, enabling tunable lasing sites and high output power.

More Related Videos

Rapid Repetition Rate Fluctuation Measurement of Soliton Crystals in a Microresonator

Rapid Repetition Rate Fluctuation Measurement of Soliton Crystals in a Microresonator

Published on: December 15, 2021

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Published on: May 25, 2016

Related Experiment Videos

Last Updated: Jan 13, 2026

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

Rapid Repetition Rate Fluctuation Measurement of Soliton Crystals in a Microresonator

Rapid Repetition Rate Fluctuation Measurement of Soliton Crystals in a Microresonator

Published on: December 15, 2021

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Published on: May 25, 2016

Area of Science:

Photonics and Laser Technology
Condensed Matter Physics
Non-Hermitian Systems

Background:

Topological lasers offer robust photonic systems but face limitations like low gain and fixed lasing sites.
Current semiconductor-based topological lasers are constrained by microcavity and resonator designs.

Purpose of the Study:

To present an all-solid-state, reconfigurable topological laser.
To overcome the limitations of semiconductor-based topological lasers.
To explore novel topological lasing phenomena and applications.

Main Methods:

Fabrication of a Su-Schrieffer-Heeger waveguide array in a disordered laser crystal (Nd:BaLaGa3O7).
Utilizing high gain from solid-state lasers for continuous-wave operation.
Experimental and theoretical analysis of topological lasing characteristics.

Main Results:

Demonstrated single-mode, continuous-wave topological lasing with over 100 mW output power.
Observed topological lasing at conventional edge sites, trivial lattice terminations, and reconfigurable arbitrary sites.
Identified non-Hermitian parity-time symmetry transition as the cause for unconventional lasing behavior.

Conclusions:

The developed solid-state topological laser is reconfigurable and site-selectable.
This work provides fundamental insights into topological phase transitions in non-Hermitian systems.
Paves the way for robust, reconfigurable topological photonic devices for advanced lasing and optical processing.