Related Experiment Video
Updated: Jan 13, 2026
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Oncogenic and immunological roles of NSUN2 in triple negative breast cancer
Ning An1, Yi-Fan Zeng2, Zhuo-Wan Tian2
1Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430079, Hubei, China.
Abstract:
Immunotherapy have led to clinical remissions in many solid tumors. However, the efficacy of immunotherapeutic monotherapy in triple-negative breast cancer (TNBC) is not very satisfactory. NSUN2 functions as a proto-oncogene in various cancers, promoting tumor cell proliferation, invasion, and metastasis. However, its role in modulating the tumor immune microenvironment, particularly in TNBC immunotherapy and its relationship with treatment sensitivity in TNBC remain to be further explored. In this study, we found that NSUN2 was highly expressed in pan-cancer, and elevated levels correlate with poor prognosis in TNBC. Furthermore, NSUN2 expression demonstrated a positive correlation with immune cell infiltration and the expression of immune checkpoint molecules. Up-regulated NSUN2 expression lowers the sensitivity of many chemotherapy drugs, and higher the sensitivity of many molecular-targeted agents. Functionally, depleted NSUN2 inhibits the proliferation and migration of TNBC cells significantly. Our study reveals the critical role of NSUN2 in regulating the immune microenvironment of TNBC, provides a theoretical foundation for its potential as a novel immunotherapy target, addresses the knowledge gap regarding NSUN2's immunoregulatory mechanisms in TNBC, and demonstrates significant clinical translational potential.
Insights
Nuclear factor NUMA1-binding protein 1 (NSUN2) is highly expressed in triple-negative breast cancer (TNBC), correlating with poor prognosis and influencing immune cell infiltration. Targeting NSUN2 may improve TNBC immunotherapy efficacy.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Immunotherapy has shown promise in solid tumors, but its efficacy in triple-negative breast cancer (TNBC) is limited.
- Nuclear factor NUMA1-binding protein 1 (NSUN2) is implicated as a proto-oncogene in various cancers, promoting tumor progression.
- The role of NSUN2 in the tumor immune microenvironment and its impact on TNBC treatment sensitivity require further investigation.
Purpose of the Study:
- To investigate the role of NSUN2 in triple-negative breast cancer (TNBC) immunotherapy.
- To explore the relationship between NSUN2 expression and TNBC treatment sensitivity.
- To elucidate NSUN2's mechanisms in regulating the TNBC immune microenvironment.
Main Methods:
- Pan-cancer analysis of NSUN2 expression.
- Correlation analysis between NSUN2 levels, prognosis, immune cell infiltration, and immune checkpoint molecules in TNBC.
- Functional studies involving NSUN2 depletion in TNBC cells.
- Assessment of NSUN2's impact on chemotherapy and molecular-targeted agent sensitivity.
Main Results:
- NSUN2 is highly expressed across cancers and linked to poor prognosis in TNBC.
- Elevated NSUN2 expression positively correlates with immune cell infiltration and immune checkpoint molecule expression.
- NSUN2 upregulation decreases sensitivity to chemotherapy drugs but increases sensitivity to molecular-targeted agents.
- Depletion of NSUN2 significantly inhibits TNBC cell proliferation and migration.
Conclusions:
- NSUN2 plays a critical role in regulating the TNBC immune microenvironment.
- NSUN2 represents a potential novel immunotherapy target for TNBC.
- Understanding NSUN2's immunoregulatory mechanisms can guide TNBC treatment strategies and offers clinical translational potential.
More Related Videos
07:59Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Related Concept Videos
01:12Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
03:03mTOR Signaling and Cancer Progression
The mTOR pathway or the...
01:33Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:55The Nucleolus