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Related Experiment Video

Updated: Jan 13, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

A Single-cell Transcriptome-wide Association Study Reveals Susceptibility Genes for Age-related Hearing Loss.

Yuanfeng Li¹, Tao Zeng², Wenyu Song¹

¹State Key Laboratory of Medical Proteomics, National Center for Protein Sciences at Beijing, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.

Genomics, Proteomics & Bioinformatics

|January 6, 2026

Summary

This study identified new genes and cell types linked to age-related hearing loss (ARHL) using a large-scale genetic analysis. Findings may guide future treatments and prevention strategies for ARHL.

Keywords:

Age-related hearing loss Drug target Genetic factor Single-cell transcriptome-wide association study Susceptibility gene

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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

Area of Science:

Genetics
Otolaryngology
Molecular Biology

Background:

Age-related hearing loss (ARHL) is the most prevalent form of hearing impairment.
Genetic factors significantly contribute to the development of ARHL.

Purpose of the Study:

To identify novel susceptibility genes and specific cell types associated with ARHL.
To explore potential therapeutic targets for ARHL through genetic association studies.

Main Methods:

A two-stage single-cell transcriptome-wide association study (scTWAS) was conducted.
Utilized data from 96,372 ARHL cases and 141,590 controls of European descent.

Main Results:

Identified 1034 gene-cell pairs and 450 genes associated with ARHL, enriched in immune, estrogen signaling, and oxidative damage pathways.
Validated 41 significant gene associations, including known genes like HLA-DRA and novel candidates such as TNF, ZC3HAV1, and SLC44A4.
Provided genetic evidence for drug repurposing candidates like NR3C2, CHRM4, and SHBG.

Conclusions:

The scTWAS expands the understanding of genetic underpinnings of ARHL.
Findings offer potential avenues for developing new treatments and preventive measures for age-related hearing loss.