[The olfactor-genital syndrome (author's transl)]

Area of Science:

• Reproductive Endocrinology
• Neuroendocrinology

Background:

• Olfacto-genital syndrome is a rare condition affecting both olfaction and reproductive functions.
• Understanding the hypothalamic-pituitary-gonadal axis is crucial for managing reproductive disorders.

Observation:

• Intravenous gonadotropin-releasing hormone (GnRH) administration at 0.025 mg resulted in increased follicle-stimulating hormone (FSH) levels.
• Higher doses of GnRH (0.1 mg twice) were required for a significant increase in luteinizing hormone (LH) serum concentrations.
• Thyrotropin-releasing hormone (TRH) stimulated normal human prolactin (hPRL) secretion, but chlorpromazine response was variable.
• One patient achieved a normal pregnancy following treatment with human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG).

Findings:

• Patients with olfacto-genital syndrome exhibit a blunted but present response of FSH and LH to GnRH stimulation.
• The hypothalamic-pituitary-adrenal axis shows a normal response to TRH, but dopaminergic regulation of prolactin may be impaired.
• Successful pregnancy is achievable with hormonal therapy.

Implications:

• Hormonal evaluation and targeted therapy can improve reproductive outcomes in patients with olfacto-genital syndrome.
• Understanding the specific GnRH and prolactin secretory dynamics is essential for personalized treatment strategies.
• This research contributes to the management of infertility associated with congenital anosmia and hypogonadotropic hypogonadism.