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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Things We Do for No Reason™: Routine CD4 testing in hospitalized patients with HIV.

Michael R Rose1, Adrienne M Johnson2, Joel N Blankson3

  • 1Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Journal of Hospital Medicine
|January 7, 2026
PubMed
Summary

CD4 testing during hospitalization for people with human immunodeficiency virus (HIV) is often unhelpful due to temporary stress-induced suppression. Focus on viral suppression and ART adherence for accurate immune status assessment.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Clinical Medicine

Background:

  • CD4 testing is standard for hospitalized people with HIV (PWH).

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  • Acute stressors and medications can temporarily lower CD4 counts, mimicking disease progression.
  • Most PWH on antiretroviral therapy (ART) have suppressed viral loads and reconstituted immune systems.