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Fever in a patient with mild acute pancreatitis caused by ulinastatin injection: A case report
Tong Wu1, Linzhen Li, Yan Zhang
1Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China.
Rationale:
The case describes a patient with mild acute pancreatitis (AP) who developed a persistent high fever during ulinastatin treatment. This highlights the possibility of drug-induced fever, which is a rare but important adverse reaction of ulinastatin and is often overlooked in clinical practice.
Patient Concerns:
A 58-year-old male patient with mild AP had a persistent high fever during the treatment with ulinastatin, but there was no evidence of infection.
Diagnoses:
Mild AP, ulinastatin-related drug fever.
Interventions:
The initial conservative treatment for AP included fasting, rehydration and taking ulinastatin. Antibiotics (ceftriaxone, later changed to imipenem) were used for suspected infection. After excluding infection, ulinastatin was discontinued.
Outcomes:
Within 48 hours of stopping ulinastatin, the patient's fever symptoms were relieved and his subsequent condition stabilized.
Lessons:
This case highlights the importance of considering drug-induced fever in clinical practice. Recognizing it promptly and discontinuing the drug can prevent unnecessary interventions and improve outcomes.
Insights
Drug-induced fever from ulinastatin is a rare adverse reaction in acute pancreatitis (AP) patients. Promptly recognizing and discontinuing ulinastatin can resolve fever and improve patient outcomes.
Area of Science:
- Clinical Medicine
- Pharmacology
Background:
- A case study involving a 58-year-old male patient with mild acute pancreatitis (AP).
- The patient experienced persistent high fever during treatment with ulinastatin.
- No evidence of infection was found, suggesting an alternative cause for the fever.
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